To sequence long strands of DNA, cloned strands having lengths longer than 100 bases are, in one embodiment, marked on one end with biotin. These strands are divided into 4 aliquots and each aliquot: (1) is uniquely chemically treated to randomly terminate the strands at the non-biotinylated end at a...http://www.google.com.tw/patents/US4729947?utm_source=gb-gplus-share專利 US4729947 - DNA sequencing
