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New molecular targets in Hodgkin and Reed-Sternberg cells

Frontiers
Here, we summarize current knowledge on characteristic molecular alterations in HL, as well as existing targeted therapies and potential novel treatments for...
10 months ago

Human leukocyte antigen (HLA) class I expression on Hodgkin¡VReed¡VSternberg cells is an EBV-independent major determinant of microenvironment composition in classic Hodgkin lymphoma

Wiley Online Library
HLA class I expression on Hodgkin¡VReed¡VSternberg cells is an EBV-independent major determinant of microenvironment composition in classic Hodgkin lymphoma.
6 months ago

Reed-Sternberg cells in Hodgkin¡¦s lymphoma present features of cellular senescence | Cell Death & Disease

Nature
Hodgkin's Lymphoma (HL) is one of the most prevailing malignancies in young adults. Reed¡VSternberg (RS) cells in HL have distinctive large...
97 months ago

Hodgkin lymphoma (Hodgkin disease) - Symptoms and causes

Mayo Clinic
Learn how this cancer differs from other lymphomas. Find out about risk factors and treatments, such as chemotherapy, radiation and bone...
6 months ago

Reed¡VSternberg-Cell Leukemia and Lactic Acidosis ¡X Unusual Manifestations of Hodgkin's Disease

The New England Journal of Medicine
Reed¡VSternberg cells are the sine qua non for the diagnosis of Hodgkin's disease. Although these giant cells were pointed out by Langhans in...
179 months ago

Part I: Hodgkin's lymphoma¡Xmolecular biology of Hodgkin and Reed-Sternberg cells

The Lancet
A characteristic feature of Hodgkin and Reed-Sternberg cells in classic Hodgkin's lymphoma is the lack of expression of surface immunoglobulin (or BCR), which...
78 months ago

Hodgkin vs. Non-Hodgkin Lymphoma: Is One More Serious?

Health
Hodgkin lymphoma has Reed-Sternberg cells, while non-Hodgkin lymphoma does not. 1 They also differ based on how they are classified.
13 months ago

Genomic analyses of microdissected Hodgkin and Reed-Sternberg cells: mutations in epigenetic regulators and p53 are frequent in refractory classic Hodgkin lymphoma

Nature
Here we analyze the genomic characteristics of 12 cHL tumors, corresponding to selected patients with diseases that are primary refractory to conventional...
69 months ago

Whole-slide image analysis identifies a high content of Hodgkin Reed-Sternberg cells and a low content of T lymphocytes in tumor microenvironment as predictors of adverse outcome in patients with classic Hodgkin lymphoma treated with ABVD

Frontiers
Whole-slide image analysis identifies a high content of Hodgkin Reed-Sternberg cells and a low content of T lymphocytes in tumor microenvironment as predictors...
17 months ago

Hodgkin's Disease with Monoclonal and Polyclonal Populations of Reed¡VSternberg Cells

The New England Journal of Medicine
Reed¡VSternberg cells with B-cell phenotypes have rearranged Vh genes; therefore, these cells arise from B cells.
350 months ago