CN101641339B - 用于预防和治疗心血管疾病的化合物 - Google Patents
用于预防和治疗心血管疾病的化合物 Download PDFInfo
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- CN101641339B CN101641339B CN2007800523498A CN200780052349A CN101641339B CN 101641339 B CN101641339 B CN 101641339B CN 2007800523498 A CN2007800523498 A CN 2007800523498A CN 200780052349 A CN200780052349 A CN 200780052349A CN 101641339 B CN101641339 B CN 101641339B
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- dimethoxy
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- dihydroquinazoline
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- 0 CC(C*(C)C*(*)**=[N+][O-])*(C)* Chemical compound CC(C*(C)C*(*)**=[N+][O-])*(C)* 0.000 description 4
- SQBKNGXWWBLWCX-UHFFFAOYSA-N COc(c(OC)c1)cc2c1N=C(c(cc1)ccc1N(CCO)CCO)NC2=O Chemical compound COc(c(OC)c1)cc2c1N=C(c(cc1)ccc1N(CCO)CCO)NC2=O SQBKNGXWWBLWCX-UHFFFAOYSA-N 0.000 description 1
- KTACWZKZFWVPAU-UHFFFAOYSA-N COc(cc1OC)cc(N=C(c(cc2)ccc2N(CCO)CCO)N2)c1C2=O Chemical compound COc(cc1OC)cc(N=C(c(cc2)ccc2N(CCO)CCO)N2)c1C2=O KTACWZKZFWVPAU-UHFFFAOYSA-N 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N OC(c1ccccc1)=O Chemical compound OC(c1ccccc1)=O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
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Abstract
Description
实施例 编号 | 化合物名称 | 对ApoA-I mRNA水 平的作用 |
38 | 3-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)-1,1-二甲基脲 | 活性 |
37 | 1-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)-3-苯基脲 | 活性 |
36 | 1-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)-3-(4-甲氧基苯基)脲 | 活性 |
实施例 编号 | 化合物名称 | 对ApoA-I mRNA水 平的作用 |
35 | 1-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)-3-甲基脲 | 活性 |
34 | N-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)异丁酰胺 | 活性 |
33 | N-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)苯甲酰胺 | 活性 |
32 | N-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)乙酰胺 | 活性 |
31 | N-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)-4-甲氧基苯甲酰胺 | 活性 |
30 | N-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)-4-甲基苯磺酰胺 | 活性 |
29 | N-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)苯磺酰胺 | 活性 |
28 | 环己基氨甲酸2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹 唑啉-2-基)-2,6-二甲基苯氧基)乙基酯 | 活性 |
27 | N-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)-4-甲基苯甲酰胺 | 活性 |
26 | 甲基氨甲酸2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑 啉-2-基)-2,6-二甲基-苯氧基)乙基酯 | 活性 |
25 | 丙基氨甲酸2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑 啉-2-基)-2,6-二甲基-苯氧基)乙基酯 | 活性 |
24 | N-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)甲磺酰胺 | 活性 |
实施例 编号 | 化合物名称 | 对ApoA-I mRNA水 平的作用 |
23 | 4-氯-N-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)苯磺酰胺 | 活性 |
22 | N-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)-4-甲氧基苯磺酰胺 | 活性 |
21 | N1-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)-N2-甲基邻苯二甲酰胺 | 活性 |
20 | 4-氯-N-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)苯磺酰胺 | 活性 |
18 | 2-(4-(2-氨基乙氧基)-3,5-二甲基苯基)-5,7-二甲氧基喹 唑啉-4(3H)-酮 | 活性 |
18 | N1-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)-N2-甲基邻苯二甲酰胺 | 活性 |
17 | 2-(4-氨基-3,5-二甲基苯基)-5,7-二甲氧基喹唑啉 -4(3H)-酮 | 活性 |
16 | 5,7-二甲氧基-2-(4-甲氧基-3,5-二甲基苯基)喹唑啉 -4(3H)-酮 | 活性 |
15 | 2-(2-氯-6-甲基吡啶-4-基)-5,7-二甲氧基喹唑啉-4(3H)- 酮 | 活性 |
14 | 2-(4-(2-羟基乙氧基)-3,5-二甲基苯基)-5,7-二甲氧基吡 啶并[2,3-d]嘧啶-4(3H)-酮 | 活性 |
13 | 2-(4-((4-乙基哌嗪-1-基)甲基)苯基)-5,7-二甲氧基喹唑 啉-4(3H)-酮 | 活性 |
12 | 2-(2,3-二氢苯并[b][1,4]二噁烯-6-基)-6,7-二甲氧基喹 唑啉-4(3H)-酮 | 活性 |
实施例 编号 | 化合物名称 | 对ApoA-I mRNA水 平的作用 |
11 | 2-(4-(双(2-羟基乙基)氨基)苯基)-6,7-二甲氧基喹唑啉 -4(3H)-酮 | 活性 |
10 | 2-(4-(双(2-羟基乙基)氨基)苯基)-5,7-二甲氧基喹唑啉 -4(3H)-酮 | 活性 |
9 | 2-(4-羟基-3-甲氧基苯基)-5,7-二甲氧基喹唑啉-4(3H)- 酮 | 活性 |
8 | 3-(3,5-二甲基-4-(2-(4-甲基哌嗪-1-基)乙氧基)苯 基)-6,8-二甲氧基异喹啉-1(2H)-酮 | 活性 |
7 | 2-(4-(2-羟基乙氧基)-3,5-二甲基苯基)-5,7-二甲氧基喹 唑啉-4(3H)-酮 | 活性 |
6 | 7-(4-羟基-3,5-二甲基苯基)-2,4-二甲氧基-1,6-萘啶 -5(6H)-酮 | 活性 |
5 | 3-(4-(2-羟基-2-甲基丙氧基)-3,5-二甲基苯基)-6,8-二 甲氧基异喹啉-1(2H)-酮 | 活性 |
4 | 2-(4-羟基-3,5-二甲基苯基)-5,7-二甲氧基喹唑啉 -4(3H)-酮 | 活性 |
3 | 3-(4-羟基-3,5-二甲基苯基)-7-(吗啉代基甲基)异喹啉 -1(2H)-酮 | 活性 |
2 | 3-(4-(2-羟基乙氧基)-3,5-二甲基苯基)-6,8-二甲氧基异 喹啉-1(2H)-酮 | 活性 |
1 | 3-(4-羟基-3,5-二甲基苯基)-6,8-二甲氧基异喹啉 -1(2H)-酮 | 活性 |
实施例 编号 | 化合物名称 | EC50 蛋白质 (μM) |
20 | 4-氯-N-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)苯磺酰胺 | 0.32 |
18 | 2-(4-(2-氨基乙氧基)-3,5-二甲基苯基)-5,7-二甲氧基喹 唑啉-4(3H)-酮 | 7.22 |
18 | N1-(2-(4-(5,7-二甲氧基-4-氧代-3,4-二氢喹唑啉-2- 基)-2,6-二甲基苯氧基)乙基)-N2-甲基邻苯二甲酰胺 | 7.29 |
17 | 2-(4-氨基-3,5-二甲基苯基)-5,7-二甲氧基喹唑啉 -4(3H)-酮 | 7.63 |
16 | 5,7-二甲氧基-2-(4-甲氧基-3,5-二甲基苯基)喹唑啉 -4(3H)-酮 | 16.46 |
15 | 2-(2-氯-6-甲基吡啶-4-基)-5,7-二甲氧基喹唑啉-4(3H)- 酮 | 3.96 |
14 | 2-(4-(2-羟基乙氧基)-3,5-二甲基苯基)-5,7-二甲氧基吡 啶并[2,3-d]嘧啶-4(3H)-酮 | 9.20 |
13 | 2-(4-((4-乙基哌嗪-1-基)甲基)苯基)-5,7-二甲氧基喹唑 啉-4(3H)-酮 | 13.72 |
实施例 编号 | 化合物名称 | EC50 蛋白质 (μM) |
12 | 2-(2,3-二氢苯并[b][1,4]二噁烯-6-基)-6,7-二甲氧基喹 唑啉-4(3H)-酮 | 9.07 |
11 | 2-(4-(双(2-羟基乙基)氨基)苯基)-6,7-二甲氧基喹唑啉 -4(3H)-酮 | 13.30 |
10 | 2-(4-(双(2-羟基乙基)氨基)苯基)-5,7-二甲氧基喹唑啉 -4(3H)-酮 | 12.11 |
9 | 2-(4-羟基-3-甲氧基苯基)-5,7-二甲氧基喹唑啉-4(3H)- 酮 | 12.08 |
8 | 3-(3,5-二甲基-4-(2-(4-甲基哌嗪-1-基)乙氧基)苯 基)-6,8-二甲氧基异喹啉-1(2H)-酮 | 2.82 |
7 | 2-(4-(2-羟基乙氧基)-3,5-二甲基苯基)-5,7-二甲氧基喹 唑啉-4(3H)-酮 | 12.16 |
6 | 7-(4-羟基-3,5-二甲基苯基)-2,4-二甲氧基-1,6-萘啶 -5(6H)-酮 | 6.52 |
5 | 3-(4-(2-羟基-2-甲基丙氧基)-3,5-二甲基苯基)-6,8-二甲 氧基异喹啉-1(2H)-酮 | 6.27 |
4 | 2-(4-羟基-3,5-二甲基苯基)-5,7-二甲氧基喹唑啉 -4(3H)-酮 | 7.93 |
3 | 3-(4-羟基-3,5-二甲基苯基)-7-(吗啉代基甲基)异喹啉 -1(2H)-酮 | 11.09 |
2 | 3-(4-(2-羟基乙氧基)-3,5-二甲基苯基)-6,8-二甲氧基异 喹啉-1(2H)-酮 | 11.35 |
1 | 3-(4-羟基-3,5-二甲基苯基)-6,8-二甲氧基异喹啉 -1(2H)-酮 | 5.42 |
2-(4-羟基-苯基)-吡喃并[2,3-b]吡啶-4-酮 | 179.47 |
Claims (11)
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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US10131640B2 (en) | 2009-03-18 | 2018-11-20 | Resverlogix Corp. | Anti-inflammatory agents |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040033480A1 (en) * | 2002-08-15 | 2004-02-19 | Wong Norman C.W. | Use of resveratrol to regulate expression of apolipoprotein A1 |
CA2617213C (en) * | 2005-07-29 | 2014-01-28 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
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US20100267752A1 (en) * | 2008-10-15 | 2010-10-21 | Gilead Palo Alto, Inc. | 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS |
JPWO2010061908A1 (ja) | 2008-11-28 | 2012-04-26 | 中外製薬株式会社 | 1−(2h)−イソキノロン誘導体 |
ES2463097T3 (es) * | 2009-01-08 | 2014-05-27 | Resverlogix Corp. | Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares |
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WO2013033270A2 (en) | 2011-08-29 | 2013-03-07 | Coferon, Inc. | Bromodomain ligands capable of dimerizing in an aqueous solution, and methods of using same |
WO2013033269A1 (en) | 2011-08-29 | 2013-03-07 | Coferon, Inc. | Bioorthogonal monomers capable of dimerizing and targeting bromodomains and methods of using same |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
US8710064B2 (en) * | 2011-10-20 | 2014-04-29 | China Medical University | 2-aryl-4-quinazolinones and their pharmaceutical compositions |
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KR102104144B1 (ko) | 2012-03-07 | 2020-04-23 | 디 인스티튜트 오브 캔서 리서치:로얄 캔서 하스피틀 | 3-아릴-5-치환-이소퀴놀린-1-온 화합물 및 그의 치료적 용도 |
PT2882714T (pt) * | 2012-08-08 | 2020-02-19 | Merck Patent Gmbh | Derivados de (aza)isoquinolinona |
DK2906531T3 (en) * | 2012-10-15 | 2018-02-05 | Resverlogix Corp | APPLICABLE COMPOUNDS IN THE SYNTHESIS OF BENZAMIDE COMPOUNDS |
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WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
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US10307407B2 (en) | 2015-02-27 | 2019-06-04 | The Regents Of The University Of Michigan | 9H-pyrimido [4,5-B] indoles as BET bromodomain inhibitors |
WO2016196065A1 (en) | 2015-05-29 | 2016-12-08 | Genentech, Inc. | Methods and compositions for assessing responsiveness of cancers to bet inhibitors |
JP2018526448A (ja) * | 2015-09-07 | 2018-09-13 | 浙江華海薬業股▲フン▼有限公司 | 一酸化窒素を放出可能なプロドラッグ分子 |
CN109071562B (zh) | 2016-02-15 | 2022-03-22 | 密执安大学评议会 | 作为bet溴结构域抑制剂的稠合1,4-氧氮杂䓬和相关类似物 |
EP3440082A1 (en) | 2016-04-06 | 2019-02-13 | The Regents of The University of Michigan | Monofunctional intermediates for ligand-dependent target protein degradation |
RU2021102253A (ru) | 2016-04-06 | 2021-03-03 | Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган | Деструкторы белка mdm2 |
US10633386B2 (en) | 2016-04-12 | 2020-04-28 | The Regents Of The University Of Michigan | BET protein degraders |
ES2857743T3 (es) | 2016-09-13 | 2021-09-29 | Univ Michigan Regents | 1,4-diazepinas fusionadas como degradadores de proteína BET |
AU2017326171B2 (en) | 2016-09-13 | 2021-12-09 | The Regents Of The University Of Michigan | Fused 1,4-oxazepines as BET protein degraders |
RU2016138751A (ru) * | 2016-09-30 | 2018-04-02 | Общество с ограниченной ответственностью "Диборнол Девелопмент" | Средство для лечения сердечно-сосудистых заболеваний |
WO2018103726A1 (zh) | 2016-12-09 | 2018-06-14 | 苏州科睿思制药有限公司 | 一种溴结构域蛋白抑制剂药物的晶型及其制备方法和用途 |
WO2018118782A2 (en) | 2016-12-20 | 2018-06-28 | Oligomerix, Inc. | Novel benzofuran, benzothiophene, and indole analogs that inhibit the formation of tau oligomers and their method of use |
WO2018118791A2 (en) | 2016-12-20 | 2018-06-28 | Oligomerix, Inc. | Novel quinazolinones that inhibit the formation of tau oligomers and their method of use |
WO2018144789A1 (en) | 2017-02-03 | 2018-08-09 | The Regents Of The University Of Michigan | Fused 1,4-diazepines as bet bromodomain inhibitors |
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US11267822B2 (en) | 2017-09-13 | 2022-03-08 | The Regents Of The University Of Michigan | BET bromodomain protein degraders with cleavable linkers |
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JP2021527136A (ja) | 2018-06-13 | 2021-10-11 | ディブリー・アーゲー | 縮合トリアゼピン誘導体の調製及びbet阻害剤としてのその使用 |
WO2020131807A1 (en) | 2018-12-17 | 2020-06-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of apol1 and methods of using same |
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WO2021107657A1 (ko) * | 2019-11-26 | 2021-06-03 | 주식회사 베노바이오 | 신규한 퀴나졸린 리독스 유도체 및 bet 억제제로서의 용도 |
EP4067352A4 (en) * | 2019-11-26 | 2023-11-29 | Benobio Co., Ltd. | NOVEL QUERCETIN REDUCTION DERIVATIVE AND ITS USE AS A BET INHIBITOR |
CN115003306A (zh) * | 2020-01-08 | 2022-09-02 | 雷斯韦洛吉克斯公司 | 用bet溴结构域抑制剂和二肽基肽酶4抑制剂的组合治疗和/或预防主要不良心血管事件(mace)的方法 |
US11801234B2 (en) | 2020-03-06 | 2023-10-31 | Vertex Pharmaceuticals Incorporated | Methods of treating APOL-1 dependent focal segmental glomerulosclerosis |
WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
WO2021257857A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Naphthyridinone compounds as jak2 v617f inhibitors |
CR20230057A (es) | 2020-07-02 | 2023-08-15 | Incyte Corp | Compuestos tríciclicos de urea como inhibidores de jak2 v617f |
WO2022006456A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic pyridone compounds as jak2 v617f inhibitors |
US11866446B2 (en) | 2020-08-26 | 2024-01-09 | Vertex Pharmaceuticals Incorporated | Inhibitors of APOL1 and methods of using same |
WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
CN115710202A (zh) * | 2021-08-23 | 2023-02-24 | 江西同和药业股份有限公司 | 一种阿帕他酮关键中间体的制备方法及其应用 |
WO2023078252A1 (en) | 2021-11-02 | 2023-05-11 | Flare Therapeutics Inc. | Pparg inverse agonists and uses thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0210342A2 (de) * | 1985-05-03 | 1987-02-04 | Dr. Karl Thomae GmbH | Arzneimittel, enthaltend Pyridinone mit antithrombotischer Wirkung |
Family Cites Families (286)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2065593A (en) | 1936-12-29 | Water-soluble diazoimino com | ||
US4608A (en) * | 1846-06-27 | Netting-machine | ||
US4448A (en) * | 1846-04-04 | Xjoel | ||
FR472489A (fr) | 1914-02-20 | 1914-12-08 | Stas Motor Ges M B H | Bague de garniture métallique pour pistons |
US2065900A (en) | 1935-03-23 | 1936-12-29 | Gen Aniline Works Inc | Dihydroxystilbene-dicarboxylic acid and a process of preparing it |
FR803619A (fr) | 1935-03-23 | 1936-10-05 | Ig Farbenindustrie Ag | Acide du type dihydroxystilbène-dicarboxylique et son procédé de préparation |
DE637259C (de) | 1935-03-24 | 1936-10-27 | I G Farbenindustrie Akt Ges | Verfahren zur Darstellung einer Dioxystilbendicarbonsaeure |
FR803201A (fr) | 1935-07-08 | 1936-09-25 | Ste Ind Chim Bale | Préparation d'acides sulfoniques |
US2071329A (en) | 1935-08-22 | 1937-02-23 | Solvay Process Co | Method of recovering phthalic anhydride |
DE652772C (de) | 1935-11-07 | 1937-11-08 | I G Farbenindustrie Akt Ges | Verfahren zur Herstellung von N-Dihydroazinen der Anthrachinonreihe |
GB728767A (en) | 1951-10-12 | 1955-04-27 | Wander Ag Dr A | 2-substituted chromone compounds, and a method of making same |
BE633049A (zh) | 1962-06-06 | |||
US3251837A (en) | 1962-09-14 | 1966-05-17 | Pfizer & Co C | Derivatives of 1, 2, 4-benzothiadiazine-1, 1-dioxides |
GB1179019A (en) | 1967-05-23 | 1970-01-28 | Produits Chimique Soc Et | Polynicotinic Esters of Flavonoids |
FR6928M (zh) | 1967-11-24 | 1969-05-05 | ||
US3600394A (en) * | 1968-05-17 | 1971-08-17 | Searle & Co | 2-aminoalkyl-3-arylisocarbostyrils |
US3773946A (en) | 1969-09-02 | 1973-11-20 | Parke Davis & Co | Triglyceride-lowering compositions and methods |
US3930024A (en) | 1969-09-02 | 1975-12-30 | Parke Davis & Co | Pharmaceutical compositions and methods |
US3862186A (en) | 1972-12-15 | 1975-01-21 | Bristol Myers Co | Process for the production of cephalexin monohydrate |
FR2244493A1 (en) | 1973-08-09 | 1975-04-18 | Pluripharm | Flavonoid amino-acid salts - for treatment of haemorrhage, circulatory disorders and atherosclerosis |
DE2349024A1 (de) | 1973-09-26 | 1975-04-10 | Schering Ag | 6beta,7beta-epoxy-1alpha,2alphamethylen-d-homo-4-pregnen-3,20-dione |
IT1050750B (it) | 1975-12-05 | 1981-03-20 | Erba Carlo Spa | Derivati della 3.4 di idro chinazolina |
GB1532682A (en) | 1976-04-27 | 1978-11-22 | Bristol Myers Co | Process for the preparation of cephadroxil |
US4159330A (en) | 1976-11-02 | 1979-06-26 | Carlo Erba S.P.A. | 2-Disubstituted phenyl-3,4-dihydro-4-oxo-quinazoline derivatives and process for their preparation |
US5098903A (en) | 1980-03-07 | 1992-03-24 | Board Of Regents Of The University Of Oklahoma | Diphenylcyclopropyl analogs as antiestrogenic and antitumor agents |
IL64542A0 (en) | 1981-12-15 | 1982-03-31 | Yissum Res Dev Co | Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them |
JPS60136512A (ja) | 1983-12-26 | 1985-07-20 | Eisai Co Ltd | 脂質代謝改善剤 |
DE3423166A1 (de) | 1984-06-22 | 1986-01-02 | Epis S.A., Zug | Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
DE3579888D1 (de) | 1984-11-08 | 1990-10-31 | Sumitomo Pharma | Carbapenemverbindungen und deren herstellung. |
DE3532279A1 (de) | 1985-09-11 | 1987-03-12 | Bayer Ag | 1,4-benzoxathiin-derivate |
EP0223403B1 (en) | 1985-10-25 | 1993-08-04 | Beecham Group Plc | Piperidine derivative, its preparation, and its use as medicament |
DE3601417A1 (de) | 1986-01-20 | 1987-07-23 | Nattermann A & Cie | 2'-alkyl-(alkenyl-) substituierte quercetine |
US4663345A (en) | 1986-04-17 | 1987-05-05 | American Home Products Corporation | Etodolac for treatment of gout |
DE3774801D1 (de) | 1986-08-29 | 1992-01-09 | Ciba Geigy Ag | Verfahren zur herstellung von aromatischen ether- und thioetherverbindungen. |
EP0272455B1 (en) | 1986-11-24 | 1993-02-10 | Fujisawa Pharmaceutical Co., Ltd. | 3-Pyrrolidinylthio-1-azabicyclo [3.2.0] hept-2-ene-2-carboxylic acid compounds |
JPH07118241B2 (ja) | 1987-10-21 | 1995-12-18 | 松下電器産業株式会社 | 器具の蓋開閉装置 |
GB8804058D0 (en) | 1988-02-22 | 1988-03-23 | Fujisawa Pharmaceutical Co | 3-alkenyl-1-azabicyclo(3 2 0)hept-2-ene-2-carboxylic acid compounds |
US4925838A (en) | 1988-03-18 | 1990-05-15 | Fujisawa Pharmaceutical Company, Ltd. | 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds |
US4963544A (en) | 1988-05-23 | 1990-10-16 | Fujisawa Pharmaceutical Company, Ltd. | 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds |
GB8926981D0 (en) | 1988-12-23 | 1990-01-17 | Ici Plc | Heterocyclic derivatives |
JPH0741442Y2 (ja) | 1989-01-31 | 1995-09-27 | シャープ株式会社 | 生体用電極保持体 |
AU6062590A (en) | 1989-07-07 | 1991-02-06 | Schering Corporation | Pharmaceutically active compounds |
FR2649612A1 (fr) | 1989-07-17 | 1991-01-18 | Rhone Poulenc Sante | Medicaments a base de derives de 1h-benzoxadiazine-4,1,2 nouveaux derives et leurs procedes de preparation |
IE64358B1 (en) | 1989-07-18 | 1995-07-26 | Ici Plc | Diaryl ether heterocycles |
US5332832A (en) | 1989-07-26 | 1994-07-26 | Procter & Gamble Pharmaceuticals, Inc. | Nitrofurantoin crystals |
GB9018134D0 (en) | 1989-09-29 | 1990-10-03 | Ici Plc | Heterocyclic derivatives |
US5244904A (en) | 1990-06-05 | 1993-09-14 | Toray Industries, Inc. | Indole derivatives |
JP2999579B2 (ja) | 1990-07-18 | 2000-01-17 | 武田薬品工業株式会社 | Dnaおよびその用途 |
IE913866A1 (en) | 1990-11-28 | 1992-06-03 | Ici Plc | Aryl derivatives |
GB9025832D0 (en) | 1990-11-28 | 1991-01-09 | Ashwell Geoffrey J | Novel films for nonlinear optical applications |
US5126351A (en) | 1991-01-24 | 1992-06-30 | Glaxo Inc. | Antitumor compounds |
MX9200299A (es) | 1991-02-07 | 1992-12-01 | Roussel Uclaf | Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen. |
JPH06504791A (ja) | 1991-04-10 | 1994-06-02 | オクタマー,インコーポレイティド | レトロウィルス複製の阻害のための方法 |
ATE159009T1 (de) * | 1991-05-10 | 1997-10-15 | Rhone Poulenc Rorer Int | Bis mono- und bicyclische aryl- und heteroarylderivate mit inhibierender wirkung auf die egf und/oder pdgf-rezeptor tyrosinkinase |
US5480883A (en) | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US5124337A (en) | 1991-05-20 | 1992-06-23 | Schering Corporation | N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase |
US5223506A (en) | 1991-06-04 | 1993-06-29 | Glaxo Inc. | Cyclic antitumor compounds |
PT100905A (pt) | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
US5250679A (en) | 1991-10-18 | 1993-10-05 | Genentech, Inc. | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor |
GB9126260D0 (en) | 1991-12-11 | 1992-02-12 | Pfizer Ltd | Therapeutic agents |
US5474994A (en) | 1992-05-26 | 1995-12-12 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A |
FR2689127B1 (fr) | 1992-03-31 | 1994-05-06 | Adir Cie | Nouvelles 3', 5' -ditertbutyl-4'-hydroxy flavones, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
US7655699B1 (en) | 1992-04-22 | 2010-02-02 | Eisai Inc. | Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors |
DE4215587A1 (de) | 1992-05-12 | 1993-11-18 | Bayer Ag | Sulfonylbenzyl-substituierte Benzo- und Pyridopyridone |
DE4215588A1 (de) | 1992-05-12 | 1993-11-18 | Bayer Ag | Biphenylmethyl-substituierte Pyridone |
GB9218334D0 (en) | 1992-08-28 | 1992-10-14 | Ici Plc | Heterocyclic compounds |
JPH0680656A (ja) | 1992-09-03 | 1994-03-22 | Mitsui Petrochem Ind Ltd | 光学活性エポキシドの製造方法 |
AU5850894A (en) | 1992-12-23 | 1994-07-19 | Procept, Inc. | Novel agents for inhibition of hiv infectivity and use therefor |
JPH0741442A (ja) | 1993-05-21 | 1995-02-10 | Sumitomo Chem Co Ltd | アセチレンアルコール誘導体およびその製造法 |
JPH0761942A (ja) | 1993-06-17 | 1995-03-07 | Sumitomo Chem Co Ltd | フェノール誘導体およびその製造法 |
JPH0725761A (ja) | 1993-07-09 | 1995-01-27 | Kureha Chem Ind Co Ltd | 軟骨保護剤 |
US5756763A (en) | 1993-07-23 | 1998-05-26 | Zaidan Hojin Biseibutsu Kagaku Kenkyukai | Pyrrolidine derivatives |
US5707547A (en) | 1993-08-03 | 1998-01-13 | Sumitomo Chemical Company, Limited | Trans-olefin compounds, method for production thereof, liquid crystal composition containing the same as active ingredient, and liquid crystal element using said composition |
JPH07118241A (ja) | 1993-09-01 | 1995-05-09 | Sumitomo Chem Co Ltd | フェノール誘導体およびその製造法 |
JPH07179380A (ja) | 1993-12-22 | 1995-07-18 | Sumitomo Chem Co Ltd | アルコール誘導体およびその製造法 |
JPH07233109A (ja) | 1994-02-24 | 1995-09-05 | Sumitomo Chem Co Ltd | 光学活性なアルコール誘導体およびその製造法 |
EP0747381B1 (en) | 1994-02-25 | 2001-10-31 | Banyu Pharmaceutical Co., Ltd. | Carbapenem derivative |
ATE202567T1 (de) | 1994-03-08 | 2001-07-15 | Otsuka Pharma Co Ltd | Phosphorsäurediester-derivate |
JPH07247289A (ja) | 1994-03-11 | 1995-09-26 | Mitsui Petrochem Ind Ltd | クロメンオキシド類の製造方法 |
FR2718329B1 (fr) | 1994-03-21 | 2002-09-20 | Rhone Poulenc Rorer Sa | Lapin transgénique sensibilisé aux dyslipoprotéinémies. |
US6048903A (en) | 1994-05-03 | 2000-04-11 | Robert Toppo | Treatment for blood cholesterol with trans-resveratrol |
US6168776B1 (en) | 1994-07-19 | 2001-01-02 | University Of Pittsburgh | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
GB2292149A (en) | 1994-08-09 | 1996-02-14 | Ferring Res Ltd | Peptide inhibitors of pro-interleukin-1beta converting enzyme |
JP3702493B2 (ja) | 1994-08-12 | 2005-10-05 | 大正製薬株式会社 | キナゾリン−4(3h)−オン誘導体 |
DE69515898T2 (de) | 1994-11-14 | 2000-08-17 | Warner Lambert Co | 6-ARYL-PYRIDO[2,3-d]PYRIMIDINE UND -NAPHTHYRIDINE ZUR HEMMUNG DER DURCH PROTEIN-TYROSIN-KINASE HERVORGERUFENEN ZELLVERMEHRUNG |
IL115256A0 (en) | 1994-11-14 | 1995-12-31 | Warner Lambert Co | 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use |
US5446071A (en) | 1994-11-18 | 1995-08-29 | Eli Lilly And Company | Methods for lowering serum cholesterol |
JP4140981B2 (ja) | 1994-12-26 | 2008-08-27 | 東菱薬品工業株式会社 | 再狭窄症及び動脈硬化症治療薬 |
US5648387A (en) | 1995-03-24 | 1997-07-15 | Warner-Lambert Company | Carboxyalkylethers, formulations, and treatment of vascular diseases |
AU5259296A (en) | 1995-04-07 | 1996-10-23 | Warner-Lambert Company | Flavones and coumarins as agents for the treatment of athero sclerosis |
EP0747051B1 (en) | 1995-06-07 | 2002-07-24 | Eli Lilly And Company | Treatment of diseases by inducing BEF-1 transcription factor |
WO1997008153A1 (fr) | 1995-08-30 | 1997-03-06 | Otsuka Pharmaceutical Factory, Inc. | Procede de production de derives de quinazolin-4-one |
US5783577A (en) | 1995-09-15 | 1998-07-21 | Trega Biosciences, Inc. | Synthesis of quinazolinone libraries and derivatives thereof |
WO1997010221A1 (en) | 1995-09-15 | 1997-03-20 | Torrey Pines Institute For Molecular Studies | Synthesis of quinazolinone libraries |
AU706262B2 (en) | 1995-10-23 | 1999-06-10 | Osteoscreen, Inc. | Compositions and methods for treating bone deficit conditions |
HU224225B1 (hu) | 1995-12-01 | 2005-06-28 | Sankyo Co. Ltd. | Tachikinin receptor antagonista hatású heterociklusos vegyületek, ezek előállítási eljárása és alkalmazásuk gyógyszerkészítmények előállítására |
US5756736A (en) | 1996-01-26 | 1998-05-26 | Syntex (U.S.A.) Inc. | Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative |
US5739330A (en) | 1996-02-05 | 1998-04-14 | Hoechst Celanese Corporation | Process for preparing quinazolones |
WO1997028118A1 (en) | 1996-02-05 | 1997-08-07 | Hoechst Celanese Corporation | Process for preparing anthranilic acids |
US5763608A (en) | 1996-02-05 | 1998-06-09 | Hoechst Celanese Corporation | Process for preparing pyrimidine derivatives |
CN1067070C (zh) | 1996-02-12 | 2001-06-13 | 新泽西州州立大学(拉特格斯) | 用作拓扑异构酶抑制剂的甲氧檗因类似物 |
PL330814A1 (en) | 1996-06-20 | 1999-06-07 | Regents Board Of | Compounds for and methods of delivering pharmaceutical preparations and their application |
US5854264A (en) | 1996-07-24 | 1998-12-29 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
KR100213895B1 (ko) | 1996-10-14 | 1999-08-02 | 박원훈 | 감귤류 과피 추출물, 이로부터 분리 정제된 헤스페리딘 또는 나린진을 포함하는 심혈관 질환 예방및 치료제 조성물 |
DE19651099A1 (de) | 1996-12-09 | 1998-06-10 | Consortium Elektrochem Ind | Mehrkomponentensystem zum Verändern, Abbau oder Bleichen von Lignin, ligninhaltigen Materialien oder ähnlichen Stoffen sowie Verfahren zu seiner Anwendung |
IL119971A (en) | 1997-01-07 | 2003-02-12 | Yissum Res Dev Co | Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids |
US6613722B1 (en) | 1997-03-07 | 2003-09-02 | Exxon Chemical Patents Inc. | Lubricating composition |
JPH10287678A (ja) | 1997-04-11 | 1998-10-27 | Kyowa Hakko Kogyo Co Ltd | ピラノアジン誘導体 |
AR012634A1 (es) | 1997-05-02 | 2000-11-08 | Sugen Inc | Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion |
JP4362638B2 (ja) | 1997-05-13 | 2009-11-11 | オクテイマー・インコーポレイテッド | pADPRTインヒビターを用いる炎症および炎症性疾患の処置法 |
US5908861A (en) | 1997-05-13 | 1999-06-01 | Octamer, Inc. | Methods for treating inflammation and inflammatory disease using pADPRT inhibitors |
CN1231215C (zh) | 1997-06-02 | 2005-12-14 | 詹森药业有限公司 | (咪唑-5-基)甲基-2-喹啉酮衍生物用作平滑肌细胞增殖抑制剂 |
IL121165A0 (en) | 1997-06-26 | 1997-11-20 | Yissum Res Dev Co | Pharmaceutical compositions containing carboxylic acids and derivatives thereof |
AU8885498A (en) | 1997-08-29 | 1999-03-22 | Takeda Chemical Industries Ltd. | Triazine derivatives, their production and use |
US20020022636A1 (en) | 1997-09-03 | 2002-02-21 | Jia-He Li | Oxo-substituted compounds, process of making, and compositions and methods for inhibiting parp activity |
US6635642B1 (en) | 1997-09-03 | 2003-10-21 | Guilford Pharmaceuticals Inc. | PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same |
US6239114B1 (en) | 1997-09-26 | 2001-05-29 | Kgk Synergize | Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols |
US6340759B1 (en) | 1997-10-02 | 2002-01-22 | Eisai Co., Ltd. | Fused pyridine derivatives |
DE69817862T2 (de) | 1997-10-28 | 2004-07-15 | Korea Institute Of Science And Technology | Naringin und naringenin als mittel zur vorbeugung oder behandlung von leber-erkrankungen |
GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
DE19756388A1 (de) | 1997-12-18 | 1999-06-24 | Hoechst Marion Roussel De Gmbh | Substituierte 2-Aryl-4-amino-chinazoline |
DE69926729T2 (de) | 1998-01-08 | 2006-06-08 | Aventis Pharmaceuticals Inc. | Transgenes kaninchen, dass ein funktionelles menschliches lipoprotein(a) exprimiert |
US6414037B1 (en) | 1998-01-09 | 2002-07-02 | Pharmascience | Pharmaceutical formulations of resveratrol and methods of use thereof |
KR100407811B1 (ko) | 1998-03-17 | 2003-12-01 | 츄가이 세이야꾸 가부시키가이샤 | 인터루킨-6 안타고니스트를 유효성분으로서 함유하는 염증성 장질환의 예방 또는 치료제 |
US6022901A (en) | 1998-05-13 | 2000-02-08 | Pharmascience Inc. | Administration of resveratrol to prevent or treat restenosis following coronary intervention |
SE9802973D0 (sv) | 1998-09-03 | 1998-09-03 | Astra Ab | Immediate release tablet |
AU5759899A (en) | 1998-09-24 | 2000-04-10 | Mitsubishi Chemical Corporation | Hydroxyflavone derivatives as tau protein kinase 1 inhibitors |
CN1148188C (zh) | 1998-10-19 | 2004-05-05 | 卫材株式会社 | 镇痛剂 |
CN1327384A (zh) | 1998-10-20 | 2001-12-19 | 韩国科学技术研究院 | 作为血浆高密度脂蛋白浓度增高剂的生物类黄酮 |
US6433187B1 (en) | 1998-12-17 | 2002-08-13 | Tularik Inc. | Certain polycyclic compounds useful as tubulin-binding agents |
US6291456B1 (en) | 1998-12-30 | 2001-09-18 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
US6399633B1 (en) | 1999-02-01 | 2002-06-04 | Aventis Pharmaceuticals Inc. | Use of 4-H-1-benzopryan-4-one derivatives as inhibitors of smooth muscle cell proliferation |
BR0008731A (pt) | 1999-03-15 | 2002-09-24 | Abbott Lab | Macrolìdeos 6-0-substituìdos, tendo atividade antibacteriana |
US6969720B2 (en) | 1999-03-17 | 2005-11-29 | Amr Technology, Inc. | Biaryl substituted purine derivatives as potent antiproliferative agents |
US6054435A (en) | 1999-03-19 | 2000-04-25 | Abbott Laboratories | 6-O-substituted macrolides having antibacterial activity |
IL145922A0 (en) | 1999-04-28 | 2002-07-25 | Aventis Pharma Gmbh | Di-aryl acid derivatives as ppar receptor ligands |
US6835755B1 (en) | 1999-06-24 | 2004-12-28 | University Of Pretoria | Naphthoquinone derivatives and their use in the treatment and control of tuberculosis |
DE19934799B4 (de) | 1999-07-28 | 2008-01-24 | Az Electronic Materials (Germany) Gmbh | Chiral-smektische Flüssigkristallmischung und ihre Verwendung in Aktivmatrix-Displays mit hohen Kontrastwerten |
JP2001131151A (ja) | 1999-11-02 | 2001-05-15 | Shionogi & Co Ltd | オレフィン誘導体の新規用途 |
JP5278983B2 (ja) | 1999-11-17 | 2013-09-04 | 塩野義製薬株式会社 | アミド化合物の新規用途 |
ATE444960T1 (de) | 1999-12-06 | 2009-10-15 | Welichem Biotech Inc | Polyhydroxystilbene und -stilbenoxide als antipsoriasismittel und proteinkinasehemmer |
FR2804679B1 (fr) | 2000-02-07 | 2002-04-26 | Clariant France Sa | Nouveaux composes phenoliques derives des dialcoxyethanals, leur procede de preparation et leur application |
ATE272600T1 (de) | 2000-02-17 | 2004-08-15 | Appleton Paper Inc | Verfahren zur herstellung von alkoxy- oder arylmethoxy-aroxyethanen |
DE60144322D1 (de) | 2000-04-27 | 2011-05-12 | Astellas Pharma Inc | Kondensierte heteroarylderivate |
US6653332B2 (en) | 2000-05-03 | 2003-11-25 | Tularik Inc. | Combination therapeutic compositions and method of use |
US6548694B2 (en) | 2000-05-23 | 2003-04-15 | Hoffman-La Roche Inc. | N-(4-carbamimidoyl-phenyl)-glycine derivatives |
JP2001335476A (ja) | 2000-05-29 | 2001-12-04 | Shionogi & Co Ltd | 三環化合物の新規用途 |
US6479499B1 (en) | 2000-06-28 | 2002-11-12 | National Science Council | 2-phenyl-4-quinazolinone compounds, 2-phenyl-4-alkoxy-quinazoline compounds and their pharmaceutical compositions |
JP2002047283A (ja) | 2000-07-04 | 2002-02-12 | Basf Ag | 新規フラボノイドおよびそれらの化粧用または皮膚科用製品における使用 |
US6541522B2 (en) | 2000-08-16 | 2003-04-01 | Insmed Incorporated | Methods of using compositions containing hypotriglyceridemically active stilbenoids |
US7723303B2 (en) | 2000-08-24 | 2010-05-25 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
AU9650201A (en) | 2000-10-02 | 2002-04-15 | Molecular Probes Inc | Reagents for labeling biomolecules having aldehyde or ketone moieties |
CA2356544C (en) | 2000-10-03 | 2006-04-04 | Warner-Lambert Company | Pyridotriazines and pyridopyridazines |
KR20030067675A (ko) | 2000-10-05 | 2003-08-14 | 후지사와 야꾸힝 고교 가부시키가이샤 | 벤자미드 화합물 |
WO2002030884A2 (en) | 2000-10-11 | 2002-04-18 | Esperion Therapeutics, Inc. | Sulfide and disulfide compounds and compositions for cholesterol management and related uses |
EP1366024A2 (en) | 2000-10-11 | 2003-12-03 | Esperion Therapeutics Inc. | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
AU3238102A (en) | 2000-10-19 | 2002-04-29 | Merck & Co Inc | Estrogen receptor modulators |
CN100375749C (zh) | 2000-11-30 | 2008-03-19 | 佳能株式会社 | 发光器件和显示器 |
JP2004521878A (ja) | 2000-12-07 | 2004-07-22 | スィーヴィー セラピューティクス インコーポレイテッド | Abca−1を上昇させる化合物 |
KR100472694B1 (ko) | 2000-12-30 | 2005-03-07 | 한국생명공학연구원 | 플라바논 유도체 및 이를 포함하는 혈중 지질 농도 관련질환의 예방 및 치료용 조성물 |
JP2002249483A (ja) | 2001-02-21 | 2002-09-06 | Koei Chem Co Ltd | アリール置換複素環式化合物の製造法 |
WO2002074307A1 (en) | 2001-03-16 | 2002-09-26 | Novogen Research Pty Ltd | Treatment of restenosis |
EP1385501A2 (en) | 2001-04-11 | 2004-02-04 | Atherogenics, Inc. | Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality |
CA2447475A1 (en) | 2001-05-25 | 2002-12-05 | Chu-Biao Xue | Hydantion derivatives as inhibitors of matrix metalloproteinases |
WO2003007959A1 (en) | 2001-07-16 | 2003-01-30 | Fujisawa Pharmaceutical Co., Ltd. | Quinoxaline derivatives which have parp inhibitory action |
EP1430038A1 (en) | 2001-08-13 | 2004-06-23 | Ciba SC Holding AG | Ultraviolet light absorbers |
US20040248950A1 (en) | 2001-08-24 | 2004-12-09 | Natsuki Ishizuka | Apo ai expression accelerating agent |
US8124625B2 (en) | 2001-09-14 | 2012-02-28 | Shionogi & Co., Ltd. | Method of enhancing the expression of apolipoprotein AI using olefin derivatives |
US7429593B2 (en) | 2001-09-14 | 2008-09-30 | Shionogi & Co., Ltd. | Utilities of amide compounds |
EP1426046A4 (en) | 2001-09-14 | 2005-11-02 | Shionogi & Co | NEW USE OF TRICYCLIC COMPOUNDS |
US6835469B2 (en) | 2001-10-17 | 2004-12-28 | The University Of Southern California | Phosphorescent compounds and devices comprising the same |
US7166368B2 (en) | 2001-11-07 | 2007-01-23 | E. I. Du Pont De Nemours And Company | Electroluminescent platinum compounds and devices made with such compounds |
US7250512B2 (en) | 2001-11-07 | 2007-07-31 | E. I. Du Pont De Nemours And Company | Electroluminescent iridium compounds having red-orange or red emission and devices made with such compounds |
US6541045B1 (en) | 2002-01-04 | 2003-04-01 | Nutraceutical Corporation | Herbal composition and method for combating inflammation |
EP1477481B1 (en) | 2002-01-28 | 2009-07-22 | Ube Industries, Ltd. | Process for producing quinazolin-4-one derivative |
ATE353013T1 (de) | 2002-02-19 | 2007-02-15 | Pfizer Italia Srl | Trizyklische pyrazolderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumor mittel |
GB0206033D0 (en) | 2002-03-14 | 2002-04-24 | Pfizer Ltd | Compounds useful in therapy |
NZ556545A (en) | 2002-03-22 | 2009-03-31 | Novartis Ag | Combination comprising a beta-hydroxy-beta-methylglutaryl-co-enzyme-A reductase inhibitor and a glucagon-like peptide-1 agonist |
MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
AU2003238157A1 (en) * | 2002-06-18 | 2003-12-31 | Sankyo Company, Limited | Fused-ring pyrimidin-4(3h)-one derivatives, processes for the preparation and uses thereof |
KR20040001144A (ko) | 2002-06-27 | 2004-01-07 | 김대경 | 신규한 적혈구 세포질형 포스포리파아제 에이 투 효소,그에 대한 항체, 이들의 용도 및 제조 방법 |
US20040033480A1 (en) | 2002-08-15 | 2004-02-19 | Wong Norman C.W. | Use of resveratrol to regulate expression of apolipoprotein A1 |
US20050080021A1 (en) | 2002-08-15 | 2005-04-14 | Joseph Tucker | Nitric oxide donating derivatives of stilbenes, polyphenols and flavonoids for the treatment of cardiovascular disorders |
US20050080024A1 (en) | 2002-08-15 | 2005-04-14 | Joseph Tucker | Nitric oxide donating derivatives for the treatment of cardiovascular disorders |
JP2005536554A (ja) | 2002-08-23 | 2005-12-02 | ユニバーシティ オブ コネチカット | 新規なビフェニル及びビフェニル様カンナビノイド |
US20040176366A1 (en) | 2002-08-30 | 2004-09-09 | Wathen Michael W | Method of preventing or treating atherosclerosis or restenosis |
EP1407774A1 (en) | 2002-09-10 | 2004-04-14 | LION Bioscience AG | 2-Amino-4-quinazolinones as LXR nuclear receptor binding compounds |
EP1398032A1 (en) | 2002-09-10 | 2004-03-17 | PheneX Pharmaceuticals AG | 4-Oxo-quinazolines as LXR nuclear receptor binding compounds |
WO2004032846A2 (en) | 2002-10-07 | 2004-04-22 | Bristol-Myers Squibb Company | Triazolone and triazolethione derivatives |
US20040132732A1 (en) | 2002-10-21 | 2004-07-08 | Wei Han | Quinazolinones and derivatives thereof as factor Xa inhibitors |
WO2004039795A2 (en) | 2002-10-29 | 2004-05-13 | Fujisawa Pharmaceutical Co., Ltd. | Amide compounds for the treatment of hyperlipidemia |
AU2003291761A1 (en) | 2002-11-04 | 2004-06-07 | Nps Pharmaceuticals, Inc. | Quinazolinone compounds as calcilytics |
EP1418164A1 (en) | 2002-11-07 | 2004-05-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | New stilbene derivatives and their use as aryl hydrocarbon receptor ligand antagonists |
AU2003283393A1 (en) | 2002-11-18 | 2004-06-15 | F. Hoffmann-La Roche Ag | Diazinopyrimidines |
AU2003293006A1 (en) | 2002-11-22 | 2004-06-18 | Japan Tobacco Inc. | Fused bicyclic nitrogen-containing heterocycles |
KR100707532B1 (ko) | 2002-12-13 | 2007-04-12 | 에프. 호프만-라 로슈 아게 | 3h-퀴나졸린-4-온 유도체 |
ITRM20020629A1 (it) | 2002-12-19 | 2004-06-20 | Sigma Tau Ind Farmaceuti | Uso di acidi alfa-feniltiocarbossilici e alfa-fenilossicarbossilici ad attivita' ipoglicemizzante e/o ipolipidemizzante. |
ATE496893T1 (de) * | 2002-12-20 | 2011-02-15 | X Ceptor Therapeutics Inc | Isochinolinonderivate und deren verwendung als medikamente |
JP2004203751A (ja) | 2002-12-24 | 2004-07-22 | Pfizer Inc | 置換6,6−ヘテロ二環式誘導体 |
EP1577288B1 (en) | 2002-12-26 | 2014-07-23 | Eisai R&D Management Co., Ltd. | Selective estrogen receptor modulators |
WO2004065392A1 (en) * | 2003-01-24 | 2004-08-05 | Smithkline Beecham Corporation | Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands |
WO2004072042A2 (en) | 2003-02-12 | 2004-08-26 | Carex S.A. | Quinoline derivative and their use for modulation of lxr activity |
WO2004092154A1 (en) | 2003-04-03 | 2004-10-28 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
JP4895806B2 (ja) | 2003-04-09 | 2012-03-14 | エクセリクシス, インク. | Tie−2モジュレータと使用方法 |
JP2004307440A (ja) | 2003-04-10 | 2004-11-04 | Kyorin Pharmaceut Co Ltd | 2−アミノ‐1,3‐プロパンジオール誘導体とその付加塩 |
EP1629000B1 (en) | 2003-04-16 | 2009-02-18 | Bristol-Myers Squibb Company | Macrocyclic isoquinoline peptide inhibitors of hepatitis c virus |
EP1631295B1 (en) | 2003-06-06 | 2010-03-03 | Arexis AB | Use of condensed heterocyclic compounds as scce inhibitors for the treatment of skin diseases |
ES2389258T3 (es) | 2003-06-17 | 2012-10-24 | Millennium Pharmaceuticals, Inc. | Composiciones y métodos para inhibir TGF-s |
WO2004113307A1 (ja) | 2003-06-18 | 2004-12-29 | Ube Industries, Ltd. | ピリミジン−4−オン化合物の製造方法 |
US20050043300A1 (en) | 2003-08-14 | 2005-02-24 | Pfizer Inc. | Piperazine derivatives |
US20050096391A1 (en) | 2003-10-10 | 2005-05-05 | Per Holm | Compositions comprising fenofibrate and rosuvastatin |
CN1925862A (zh) | 2003-10-10 | 2007-03-07 | 雷斯弗洛吉克斯公司 | 与egr-1增强子元件有关的疾病的治疗 |
WO2005042712A2 (en) | 2003-10-28 | 2005-05-12 | Reddy Us Therapeutics, Inc. | Heterocyclic compounds and methods of making and using thereof |
US20070060601A1 (en) | 2003-12-19 | 2007-03-15 | Arrington Kenneth L | Mitotic kinesin inhibitors |
US20080188527A1 (en) | 2003-12-23 | 2008-08-07 | Cashman John R | Synthetic Compounds and Derivatives as Modulators of Smoking or Nicotine Ingestion and Lung Cancer |
TW200536830A (en) | 2004-02-06 | 2005-11-16 | Chugai Pharmaceutical Co Ltd | 1-(2H)-isoquinolone derivative |
JPWO2005115993A1 (ja) * | 2004-05-31 | 2008-03-27 | 萬有製薬株式会社 | キナゾリン誘導体 |
GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
WO2006012577A2 (en) | 2004-07-22 | 2006-02-02 | Bayer Pharmaceuticals Corporation | Quinazolinone derivatives useful for the regulation of glucose homeostasis and food intake |
US20070218155A1 (en) | 2004-08-20 | 2007-09-20 | Kuhrts Eric H | Methods and compositions for treating dyslipidaemia |
US7846915B2 (en) | 2004-10-20 | 2010-12-07 | Resverlogix Corporation | Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases |
EP1844023A1 (en) | 2004-12-31 | 2007-10-17 | Sk Chemicals Co., Ltd. | Quinazoline derivatives for the treatment and prevention of diabetes and obesity |
CR9465A (es) | 2005-03-25 | 2008-06-19 | Surface Logix Inc | Compuestos mejorados farmacocineticamente |
CA2617213C (en) | 2005-07-29 | 2014-01-28 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
AU2006307046A1 (en) | 2005-10-27 | 2007-05-03 | Msd K.K. | Novel benzoxathiin derivative |
US20070197509A1 (en) | 2005-12-21 | 2007-08-23 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
WO2007131517A1 (en) | 2006-05-12 | 2007-11-22 | Pharmathen S.A. | Pharmaceutical formulation containing an hmg-coa reductase inhibitor and method for the preparation thereof |
US20080085911A1 (en) | 2006-10-10 | 2008-04-10 | Reliant Pharmaceuticals, Inc. | Statin and omega-3 fatty acids for reduction of apo-b levels |
EP2097391A1 (en) | 2006-11-15 | 2009-09-09 | High Point Pharmaceuticals, LLC | 2- ( 2 -hydroxyphenyl) -quinazolin-4-ones useful for treating obesity and diabetes |
CA2672373C (en) | 2006-12-19 | 2011-08-30 | Pfizer Products Inc. | Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
US8053440B2 (en) | 2007-02-01 | 2011-11-08 | Resverlogix Corporation | Compounds for the prevention and treatment of cardiovascular diseases |
ES2308916B1 (es) | 2007-03-22 | 2009-10-29 | Consejo Superior De Investigaciones Cientificas | Compuesto inhibidor dual de las enzimas pde7 y/o pde4, composiciones farmaceuticas y sus aplicaciones. |
EP2005941A3 (de) | 2007-06-01 | 2009-04-01 | Henkel AG & Co. KGaA | Zellverjüngende Zusammensetzungen |
WO2008152471A1 (en) | 2007-06-12 | 2008-12-18 | Coley Pharmaceutical Group, Inc. | Quinazoline derivative useful as toll-like receptor antagonist |
CN101687821A (zh) | 2007-06-21 | 2010-03-31 | Irm责任有限公司 | 蛋白激酶抑制剂及其使用方法 |
WO2009084693A1 (ja) | 2007-12-28 | 2009-07-09 | Mitsubishi Tanabe Pharma Corporation | 抗癌剤 |
PL2346837T3 (pl) | 2008-06-26 | 2015-07-31 | Resverlogix Corp | Sposoby wytwarzania pochodnych chinazolinonu |
WO2010015520A1 (de) | 2008-08-05 | 2010-02-11 | Boehringer Ingelheim International Gmbh | Substituierte naphthyridine und ihre verwendung als arzneimittel |
EP2331564A4 (en) | 2008-10-06 | 2013-02-20 | Carolus Therapeutics Inc | PROCESS FOR TREATMENT OF IGNITION |
JP5490811B2 (ja) | 2008-10-30 | 2014-05-14 | スルコメッド エルエルシー | アポaに対して活性なチエノトリアゾロジアゼピン誘導体 |
WO2010056910A2 (en) | 2008-11-12 | 2010-05-20 | Carolus Therapeutics, Inc. | Methods of treating cardiovascular disorders |
ES2463097T3 (es) | 2009-01-08 | 2014-05-27 | Resverlogix Corp. | Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares |
SG174252A1 (en) | 2009-03-06 | 2011-10-28 | Hoffmann La Roche | Heterocyclic antiviral compounds |
EP2408454A2 (en) | 2009-03-18 | 2012-01-25 | Resverlogix Corp. | Novel anti-inflammatory agents |
NZ596117A (en) | 2009-04-22 | 2014-10-31 | Resverlogix Corp | Novel anti-inflammatory agents |
EP2424521A4 (en) | 2009-04-29 | 2015-03-04 | Amarin Pharmaceuticals Ie Ltd | PHARMACEUTICAL COMPOSITIONS COMPRISING EPA AND CARDIOVASCULAR AGENT AND METHODS OF USE |
ES2353093B1 (es) | 2009-05-20 | 2012-01-03 | Consejo Superior De Investigaciones Científicas (Csic) | Uso de derivados de quinazolinas y sus composiciones farmacéuticas en enfermedades neurodegenerativas. |
GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
DE102010048800A1 (de) | 2010-10-20 | 2012-05-10 | Merck Patent Gmbh | Chinoxalinderivate |
GB201018147D0 (en) | 2010-10-27 | 2010-12-08 | Glaxo Group Ltd | Method of treatment |
AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
EP2675445A1 (en) | 2011-02-16 | 2013-12-25 | Pivotal Therapeutics, Inc. | Statin and omega 3 fatty acids (epa, dha and dpa) for use in cardiovascular diseases |
EP2721031B1 (en) | 2011-06-17 | 2016-01-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
SG11201401082XA (en) | 2011-09-30 | 2014-04-28 | Kineta Inc | Anti-viral compounds |
ES2745471T3 (es) | 2011-11-01 | 2020-03-02 | Resverlogix Corp | Formulaciones orales de liberación inmediata para quinazolinonas sustituidas |
US20130281399A1 (en) | 2012-04-19 | 2013-10-24 | Rvx Therapeutics Inc. | Treatment of diseases by epigenetic regulation |
US20130281398A1 (en) | 2012-04-19 | 2013-10-24 | Rvx Therapeutics Inc. | Treatment of diseases by epigenetic regulation |
US20130281397A1 (en) | 2012-04-19 | 2013-10-24 | Rvx Therapeutics Inc. | Treatment of diseases by epigenetic regulation |
EP2864336B1 (en) | 2012-06-06 | 2016-11-23 | Constellation Pharmaceuticals, Inc. | Benzo[b]isoxazoloazepine bromodomain inhibitors and uses thereof |
DK2906531T3 (en) | 2012-10-15 | 2018-02-05 | Resverlogix Corp | APPLICABLE COMPOUNDS IN THE SYNTHESIS OF BENZAMIDE COMPOUNDS |
KR101991148B1 (ko) | 2012-10-15 | 2019-06-19 | 알베마를 코포레이션 | 2-아미노-4,6-디메톡시벤즈아미드 및 기타 벤즈아미드 화합물의 합성 방법 |
WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
AU2013365926B9 (en) | 2012-12-21 | 2019-01-17 | Zenith Epigenetics Ltd. | Novel heterocyclic compounds as bromodomain inhibitors |
CA2897448A1 (en) | 2013-01-08 | 2014-07-17 | Jerome Schentag | Activation of the endogenous ileal brake hormone pathway for organ regeneration and related compositions, methods of treatment, diagnostics, and regulatory systems |
WO2014134583A2 (en) | 2013-02-28 | 2014-09-04 | Washington University | Methods of treatment of human cytomegalovirus infection and diseases with bromodomain inhibitors |
JP6401773B2 (ja) | 2013-03-11 | 2018-10-10 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | Betブロモドメイン阻害剤およびこれを用いる治療方法 |
AU2014244426B2 (en) | 2013-03-14 | 2019-02-28 | Convergene Llc | Methods and compositions for inhibition of bromodomain-containing proteins |
ES2685269T3 (es) | 2013-03-27 | 2018-10-08 | F. Hoffmann-La Roche Ag | Marcadores genéticos para predecir el grado de respuesta al tratamiento |
TWI530499B (zh) | 2013-03-28 | 2016-04-21 | 吉李德科學股份有限公司 | 作為溴結構域(bromodomain)抑制劑之苯並咪唑酮衍生物類 |
US20160206617A1 (en) | 2013-08-21 | 2016-07-21 | Resverlogix Corp. | Compositions and therapeutic methods for accelerated plaque regression |
WO2015025228A2 (en) | 2013-08-21 | 2015-02-26 | Resverlogix Corp. | Compositions and therapeutic methods for accelerated plaque regression |
US9814728B2 (en) | 2013-09-20 | 2017-11-14 | Saint Louis University | Inhibition of DUX4 expression using bromodomain and extra-terminal domain protein inhibitors (BETi) |
MX2016009663A (es) | 2014-01-23 | 2016-11-17 | H Lee Moffitt Cancer Ct & Res | Derivados de icariina. |
PT3174995T (pt) | 2014-07-30 | 2020-10-15 | Hoffmann La Roche | Marcadores genéticos para prever o tipo de resposta ao tratamento com um fármaco de aumento do hdl ou mimetizador do hdl |
WO2016123054A2 (en) | 2015-01-26 | 2016-08-04 | The University Of North Carolina At Chapel Hill | Kinase drug combinations and methods of use thereof |
US20180104232A1 (en) | 2015-03-12 | 2018-04-19 | The University Of Chicago | Methods for determining prognosis for breast cancer patients |
CN114984016A (zh) | 2015-03-13 | 2022-09-02 | 雷斯韦洛吉克斯公司 | 用于治疗补体相关疾病之组合物及治疗方法 |
RU2017142394A (ru) | 2015-05-08 | 2019-06-10 | Президент Энд Феллоус Оф Гарвард Колледж | Целевой отбор пациентов для лечения производными кортистатина |
US10702527B2 (en) | 2015-06-12 | 2020-07-07 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
CN106265679A (zh) | 2015-06-28 | 2017-01-04 | 复旦大学 | 溴结构域蛋白抑制剂在制备抗hiv-1潜伏治疗药物中的用途 |
US20180200261A1 (en) | 2015-07-20 | 2018-07-19 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
WO2017037567A1 (en) | 2015-09-03 | 2017-03-09 | Pfizer Inc. | Regulators of frataxin |
US9896663B2 (en) | 2016-03-11 | 2018-02-20 | Peter Maccallum Cancer Institute | Leukaemia stem cell line, its method of production and uses thereof |
WO2017192691A1 (en) | 2016-05-03 | 2017-11-09 | Biogen Ma Inc. | Cell culture containing bromodomain inhibitors |
CN106176753A (zh) | 2016-07-15 | 2016-12-07 | 南方医科大学 | Rvx‑208作为hiv‑1潜伏感染逆转剂的应用 |
WO2018103726A1 (zh) | 2016-12-09 | 2018-06-14 | 苏州科睿思制药有限公司 | 一种溴结构域蛋白抑制剂药物的晶型及其制备方法和用途 |
-
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- 2007-02-01 US US11/670,238 patent/US8053440B2/en active Active
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- 2007-02-01 WO PCT/CA2007/000146 patent/WO2008092231A1/en active Application Filing
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- 2010-03-22 HK HK10102977.1A patent/HK1136283A1/xx unknown
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- 2015-10-26 US US14/922,645 patent/US20160106750A1/en not_active Abandoned
-
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- 2017-09-20 US US15/710,200 patent/US10532054B2/en active Active
-
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- 2019-12-09 US US16/707,559 patent/US20200352946A1/en not_active Abandoned
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- 2021-06-01 US US17/335,960 patent/US20210361656A1/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0210342A2 (de) * | 1985-05-03 | 1987-02-04 | Dr. Karl Thomae GmbH | Arzneimittel, enthaltend Pyridinone mit antithrombotischer Wirkung |
Cited By (2)
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US10131640B2 (en) | 2009-03-18 | 2018-11-20 | Resverlogix Corp. | Anti-inflammatory agents |
US10111885B2 (en) | 2015-03-13 | 2018-10-30 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
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